Inflammation and pancreatic cancer: disease promoter and new therapeutic target

摘要: Chronic inflammation has a certain impact on the carcinogenesis of digestive organs. The characteristic tissue structure pancreatic cancer, desmoplasia, results from inflammatory processes induced by cancer cells and stromal cells. Concerning progression recent research clarified pivotal role tumor-stromal interaction, which promotes development an invasive phenotype provides survival advantages against chemotherapeutic agents or immune surveillance. Tumor such as stellate establish microenvironment that protects through complex interactions. acts niche for stem therapy-resistance disease recurrence develop. Inhibition functions restoration reaction therapeutic benefits enhance efficacy conventional therapies. Some advances in this field are now under evaluation clinical settings, but many problems must be overcome to radical therapy cancer. This review summarizes current knowledge about tumor-promoting functions, system modulation strategies targeting interactions