The Circadian Binding of CLOCK Protein to the Promoter of C/ebpα Gene in Mouse Cells

摘要: C/EBPα plays important roles in metabolism as well the maintenance of energy homeostasis. Here we describe loss circadian oscillation C/ebpα expression liver Clock mutant mice. Reporter assays indicate and Bmal significantly induced gene whereas Cry suppressed. Real time reporter showed that two mutated E-boxes disrupted promoter dependent-oscillation. Chromatin immunoprecipitation suggests can bind to with a manner vivo. Thus, transcription is under control core clock component, Clock. The data disturbances may affect metabolic abnormalities through pathway liver.