Acid Angiotensinase, Renin, and Acid Adenosine Triphosphatase in Rat Kidney Lysosomes
作者： MASAO MATSUNAGA , JUN KIRA , NOBORU SAITO , KOICHI OGINO , MASAO TAKAYASU
DOI: 10.1253/JCJ.32.137
关键词:
摘要: 1. Kidney angiotensinases are located in two kinds of subcellular fraction-lysosomal and microsomal. Lysosomal angiotensinase is active at an acid pH inhibited by DFP, suggesting a relationship to plasma angiotensinase. Most the activity was released from particles freezing thawing. The microsomal enzyme near neutral pH, activated calcium ion EDTA . 2. About 70 per cent renin lysosomal fraction rat kidney freeze-thaw method. It revealed only one peak on either Sephadex G-100 gel filtration or DEAE-cellulose column chromatography. molecular weight calculated as 40, 000-50, 000. 3. At least three components ATPase were found
sci-hub.se 参考文章(17)
Elbert A. Peterson, Herbert A. Sober, [1] Column chromatography of proteins: Substituted celluloses Methods in Enzymology. ,vol. 5, pp. 3- 27 ,(1962) , 10.1016/S0076-6879(62)05183-6
Khairallah Pa, Page Ih, Bumpus Fm, Smeby Rr, DISTRIBUTION AND METABOLIC FATE OF ANGIOTENSIN II AND VARIOUS DERIVATIVES. Canadian Medical Association Journal. ,vol. 90, pp. 190- 193 ,(1964)
P Andrews, Estimation of the molecular weights of proteins by Sephadex gel-filtration. Biochemical Journal. ,vol. 91, pp. 222- 233 ,(1964) , 10.1042/BJ0910222
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
C LAPRESLE, T WEBB, The purification and properties of a proteolytic enzyme, rabbit cathepsin E, and further studies on rabbit cathepsin D. Biochemical Journal. ,vol. 84, pp. 455- 462 ,(1962) , 10.1042/BJ0840455
R. M. Bock, Nan-Sing. Ling, Devices for Graident Elution in Chromatography Analytical Chemistry. ,vol. 26, pp. 1543- 1546 ,(1954) , 10.1021/AC60094A004
D. Regoli, B. Riniker, H. Brunner, The enzymatic degradation of various angiotensin II derivatives by serum, plasma or kidney homogenate Biochemical Pharmacology. ,vol. 12, pp. 637- 646 ,(1963) , 10.1016/0006-2952(63)90039-X
Erwin Haas, Hildegard Lamfrom, Harry Goldblatt, A simple method for the extraction and partial purification of renin. Archives of Biochemistry and Biophysics. ,vol. 48, pp. 256- 260 ,(1954) , 10.1016/0003-9861(54)90339-2
KOICHI OGINO, MASATO MATSUNAGA, NOBORU SAITO, JUN KIRA, MASAO TAKAYASU, KATSUHIKO ONO, Renin and Acid Adenosine Triphosphatase as Lysosomal Enzymes Japanese Circulation Journal-english Edition. ,vol. 31, pp. 1- 8 ,(1967) , 10.1253/JCJ.31.1
Ejvind Kemp, Inger Rubin, Lloyd M. Jackman, D. R. Sparrow, Molecular Weight of Renin Determined by Sephadex Gel-filtration. Acta Chemica Scandinavica. ,vol. 18, pp. 2403- 2403 ,(1964) , 10.3891/ACTA.CHEM.SCAND.18-2403