Serum levels of bioactive IGF1 and physiological markers of ageing in healthy adults
作者： Poul Frølund Vestergaard , Mette Hansen , Jan Frystyk , Ulrick Espelund , Jens S Christiansen
DOI: 10.1530/EJE-13-0661
关键词:
摘要: OBJECTIVE Senescent changes in body composition and muscle strength are accompanied by reduced production of GH IGF1, but the causal relationship remains elusive. We speculate that serum bioactive measured IGF1 kinase receptor activation assay, is closer related to human physiological ageing than total immunoassay. DESIGN conducted a cross-sectional study 150 adult males females, between 20 70 years. After an overnight fasting, levels IGF-binding protein 1 (IGFBP1) IGFBP3 were assessed. Furthermore, was measured. RESULTS Total higher females (P=0.048). Bioactive identical (P=0.31), decreasing with age. tended decrease more age compared (-1.48 vs -0.89 percent/year, P=0.052). fat (TBF) lower BMI (P<0.001 P=0.005), both increased Knee extension elbow flexion force (P=0.001 P=0.001), decreased genders. Total not positively correlated TBF, knee function males. In multiple linear regression, only predicted whereas IGFBP1 IGF1. CONCLUSIONS tends lesser extent measures or strength. Therefore, circulating does appear be better biomarker
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