The relationship between cochlea and kidney.

摘要: The not uncommon association in clinical practice of problems existing simultaneously the kidney and ear, prompted a closer look at these two distant organs, revealing fact that they may be comparable variety ways. Anatomical similarities were seen especially ultra-structural level. Physiological mechanisms fluid electrolyte balance are present both this common function is reflected similar pharmacological actions certain drugs. Congenital syndromes which have renal hearing defects been subject much investigation attempting to relate single etiological process pathogenesis. To investigate possible existence shared antigenicity tools immunochemistry immunohistochemistry employed experimental studies comparing with lateral cochlear wall. animals chosen rat guinea pig. Anti-rat sera anti-guinea pig produced using goat or rabbit respectively as antibody producing animal. In order produce antisera, specimens stria vascularis dissected from cochlea. collected then placed saline Complete Freunds Adjuvant, emulsified injected into subcutaneous sites rabbits. After about 10 days blood was withdrawn serum extracted blood. This crude used subsequent experiments anticochlea (AC Ab). manner glomerular basement membrane prepared (AGBM Ab). Two methods immunofluorescent staining used, namely, indirect direct method. method, frozen sections normal cochlea tissue treated previously AC Ab AGBM counterstained Fluorescein labeled anti-rabbit gamma globulin (GARG-Fl). method pigs had either stained directly GARG-Fl. third part experiments, left each animal taken for light histology. The results summarized Tables I, II, III. Of marked significance our observation capable tubular epithelium. presents compelling evidence antigenically epithelial components. In conclusion, there fascinating similarity between kidney. extends through modalities. There even possibility components.