The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
作者： Ruey-Hwa Chen , Won-Jing Wang , Jean-Cheng Kuo
DOI: 10.1007/S11373-005-9063-5
关键词:
摘要: Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits potent cytoskeletal reorganization effect is capable modulating integrin inside-out signaling. Using this understanding function framework, we discuss the functional mechanisms kinase regulating death-associated morphological signaling events. Furthermore, potential role to be drug target also discussed.
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