Genetic and lifestyle risk factors for advanced liver disease among men and women

摘要: BACKGROUND AND AIM Liver disease is traditionally categorized as alcoholic and non-alcoholic. We studied various risk factors predictive of advanced non-viral liver in general population analyzed the interaction between these alcohol consumption. METHODS Persons without underlying who participated Health2000 or FINRISK studies 1992-2012 comprised a cohort 41 260 individuals. Pattern consumption metabolic, lifestyle-related, anthropometric parameters were with Cox regression analysis using severe hospitalization, cancer, death end-point. Viral diseases excluded. RESULTS A total 355 events occurred during mean 12.4-year follow-up (511 789 person-years). In multivariate model, age (hazard ratio [HR] 1.03, P = 0.0083 for men; HR 1.04, P = 0.0198 women), waist-to-hip (WHR) (HR 1.52, P = 0.0006 1.58, P = 0.0167 patatin-like phospholipase-containing domain 3 mutations 1.9, P = 0.024 2.7, P = 0.0109 weekly binge drinking 2.4, P = 0.0024 7.4, P < 0.0001 women) predicted development disease. Among men, diabetes P = 0.0002), average 10 g/day 1.1, P = 0.0022), non-married status P = 0.0397 single; P = 0.0002 widowed/separated), serum high-density lipoprotein 2.2, P = 0.0022) non-high-density cholesterol 1.2, P = 0.0237) additional factors. Alcohol intake increased especially among persons high WHR (P 0.009). CONCLUSIONS Age, haplotype, increase found strong synergism central obesity. Binge an factor.