Primary adenoid cystic carcinoma of the skin. A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma.

摘要: An adenoid cystic carcinoma of the skin was compared with three similar neoplasms salivary glands and an basal cell carcinoma, from unrelated cases. The histological immunocytochemical details these tumors were analyzed in attempt to determine whether or not their differing clinical behaviors would be reflected pathologic dissimilarities. Although single did recur metastasize over a 10-year follow-up period, its morphologic biochemical features identical those biologically aggressive gland tumors. All four carcinomas contained carcinoembryonic antigen, epithelial membrane salivary-type amylase, alpha-lactalbumin, all bound peanut agglutinin. Three expressed positivity for S100 protein, two low-molecular-weight cytokeratin. In contrast, none immunoreactive beta-2-microglobulin, only one displayed blood group isoantigen positivity. negative immunological determinants, but it results should regarded as preliminary, appears that is pathologically distinct uniform entity, occurs glands. However, behavior this tumor cannot predicted on basis immunohistochemical morphological studies. Finally, histopathologically immunocytochemically separable cutaneous carcinoma.