Effect of late modulation of nitric oxide production on Murine lupus

摘要: Abstract MRL/MpJ- Fas lpr (MRL- ) and New Zealand Black/White (NZB/W) mice develop spontaneous autoimmune disease characterized by autoantibody production glomerulonephritis that progresses in parallel with increasing systemic nitric oxide (NO) production. A previously published study from our laboratory indicated oral administration of the synthase inhibitor N G -monomethyl- l -arginine (NMMA) before onset clinical significantly decreased renal joint pathology MRL- mice. To characterize effect late modulation NO murine SLE, we administered NMMA and/or restricted dietary arginine after two models SLE. When receiving combined restriction, had reduced scores NZB/W lower than control These results indicate modulating diminishes severity although not as effectively treating onset.