Bile benzo[a]pyrene concentration and hepatic CYP1A induction in hypoxic adult tilapia (Oreochromis niloticus).

摘要: Aquatic hypoxia is a seasonal condition in some coastal and continental wetlands where co-exposure with polycyclic aromatic hydrocarbons (PAHs) pollution may be detrimental to the biota. In present study, adult tilapia, an euryoxic fish of high economic importance, were intraperitoneally injected benzo[a]pyrene (BaP) (20 mg kg(-1)) then exposed graded assess combined effects on detoxification fitness parameters. Seventy-two hours after stepped decrease dissolved oxygen (<2 L(-1)), BaP treatment resulted significant diminution biliary concentration (70% normoxic group) increase blood glucose levels (2.17-fold compared group). These returned control values following 48 h exposure. BaP-induced CYP1A mRNA unaffected by hypoxia, suggesting that reduced bile related protein amount or enzyme activities. LDH levels, lactate hematocrit remained without change, no extreme for tilapia short-term BaP-hypoxia challenge. Our results indicate targeted metabolism elimination, probably favoring storage tissues.