Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation

摘要: Adaptation of glutamatergic transmission, including the trafficking AMPA receptor subunits, serves as an important mechanism underlying long-term neuronal plasticity under several pathophysiological conditions, pain. Meanwhile, anterior cingulate cortex (ACC) is found to be critically involved in central processing and modulation noxious stimulus, although neuroadaptation ACC has not yet been well established setting chronic To address these issues, present work was undertaken explore adaptation subunits neurons rats with inflammation left hindpaw induced Complete Freund's Adjuvant (CFA). The results showed increased receptor-mediated evoked EPSC neurons, indicating enhanced basal transmission. Furthermore, distribution synaptic GluR1 subunit observed neurons. We conclude that peripheral significantly enhances insertion which consequently increases excitatory transmission during This investigation may clarify, at least partially, supraspinal for pain by inflammation.