Localization of κ-opioid receptor mRNA in neuronal subpopulations of rat sensory ganglia and spinal cord
作者： Martin K.-H. Schäfer , Michael Bette , Horacio Romeo , Wilhelm Schwaeble , Eberhard Weihe
DOI: 10.1016/0304-3940(94)91046-4
关键词:
摘要: A partial cDNA encoding a kappa-opioid receptor was isolated and used to generate specific 35S-labeled probes investigate the gene expression of in sensory, sympathetic spinal neurons rat by situ hybridization. subpopulation mainly small medium-sized within dorsal root trigeminal ganglia expressed kappa-receptor mRNA, but no signal detectable superior cervical ganglion. kappa-Receptor mRNA distributed over throughout horn laminae VII/VIII. Highest concentrations positive were seen I/II, lamina X lateral nucleus. alpha-Motoneurons glial cells not labeled. This distribution indicates preferential functions kappa-receptors sensory signalling with particular importance nociception.
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