Novel Strategies in Anti-Platelet Treatment for Coronary Artery Disease

摘要: Treatment with oral anti-platelet agents constitutes a cornerstone in the therapy of coronary artery disease. Coronary angioplasty and stent implantation improved disease especially treatment acute myocardial infarction. Implementation glycoprotein IIb/IIIa inhibition further advanced as central component syndromes. Sustained prevention reocclusion was achieved when dual had been introduced reduced risk thrombosis to ~1% following elective stenting stable However, targeting more complex lesions or performing intervention states increased platelet reactivity such syn- dromes diabetic patients is still associated higher thrombosis. Additionally, incomplete ADP- receptor by thienopyridine contributes cardiovascular events mortality after intervention. This review describes underlying pathophysiology leading atherothrombosis contributing well pharmacological approach prevent it therapy. It summarizes assess- ment different analytical methods aggregation, function analyzers, index. Impaired clopidogrel responsiveness its implication for adverse are discussed. Current strategies improving efficacy next generation substances novel thienopyridines non-thienopyridine P2Y12-receptor blocking addressed. Finally, we discuss potential von-Willebrand factor aptamers compared inhibitors