Evolutionary correlation between control region sequence and restriction polymorphisms in the mitochondrial genome of a large Senegalese Mandenka sample.

摘要: We present here the first comparative analysis at population level between Restriction Fragment Length Polymorphism (RFLP) and control region sequence polymorphism in a large homogeneous Senegalese Mandenka sample. Eleven RFLP haplotypes 60 different sequences are found 119 individuals, revealing that very high of mtDNA diversity can be maintained small population. A neighbor-joining tree an molecular variance show associated with given restriction haplotype evolutionarily highly correlated: sequencing generally leads to subtyping haplotypes. Evolutionary relationships among inferred from site differences good agreement those data. single difference is observed likely due homoplasy having occurred region. Selective neutrality tests on both data accept hypotheses equilibrium. The deep coalescence times (exceeding 50,000 yr) two most frequent confirm Niokolo has not passed through recent bottleneck gene flow West African populations despite ethnic differences.