Pyridone Annulation via Tandem Curtius Rearrangement/6π-Electrocyclization: Total Synthesis of (−)-Lyconadin C
作者： Xiayun Cheng , Stephen P. Waters
DOI: 10.1021/OL401954F
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摘要: A concise, enantioselective total synthesis of the Lycopodium alkaloid (−)-lyconadin C was achieved in 12 steps and high overall yield. Key features include construction a luciduline congener through Mannich-type cyclization one-pot, tandem Curtius rearrangement/6π-electrocyclization to fashion 2-pyridone system lyconadin C.
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