摘要: Publisher Summary This chapter discusses the eosinophil effector mechanism. The presence of eosinophils in asthmatic sputum was reported 1889, and a positive association between circulating levels asthma made 1922. Circumstantial evidence linking began to accrue when eosinophilic infiltration airways found be regular feature fatal mucosal biopsies obtained from patients. mechanisms by which selectively accumulate areas allergic inflammation involve interactions via adhesion molecules, chemoattractants, prolonged tissue survival delaying apoptosis. role pathogenesis is mediated part release eosinophil-specific granular proteins. four principal basic proteins secondary granules are discussed chapter. Eosinophils possess unique array biological functions. As granulocytes, they contribute releasing cytotoxic granule proteins, lipid mediators, oxygen free radicals, cytokines. By these actions, involved initiation perpetuation airway asthma.
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