Toxicology of Toluene Diisocyanate

摘要: In studies on animals, toluene diisocyanate (TDI) was a contact and respiratory sensitizer, not toxic by the oral or dermal routes, but irritating, inhalation. The tract target in acute, subchronic, chronic exposure studies. Typically, at concentrations of above 0.1 ppm (parts per million), clinical signs nasal irritation were evident, histopathological investigations revealed rhinitis epithelial hyperplasia passages. With increasing concentration, effects more severe; affected larynx, trachea, lung; and, eventually, body weight survival. carcinogenicity TDI to rats mice investigated. By inhalation, there no treatment-related increase tumor incidence either species highest concentration tested (0.15 ppm). Effects seen as turbinates both species, reduced gain mice. Through administration dissolved corn oil (up 120 mg/kg/day), increased number types seen. This route is questionable relevance occupational exposure. dosing solutions known have degraded, would hydrolyze diaminotoluene acidic stomach environment. Several vitro tests for genotoxicity gave positive results, which can be ascribed degradation solvents. properly conducted assays, vivo negative genotoxicity. two-generation reproduction study rats, reproductive indices 0.3 TDI, elicited toxicity generations. developmental evidence minimal fetotoxicity presence maternal 0.5 ppm, with ppm. No embryotoxicity teratogenicity observed.