Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.

作者: Nibaldo C. Inestrosa , Juan A. Godoy , Jessica Y. Vargas , Macarena S. Arrazola , Juvenal A. Rios

DOI: 10.1007/S12017-013-8242-1

关键词:

摘要: … nicotine, an unselective α7-nAChR agonist, protects from morphological and synaptic impairments … We studied whether or not nicotine has a protective role in the synaptic impairment …

参考文章(103)
Kelly, T. Dineley, Beta-amyloid peptide - nicotinic acetylcholine receptor interaction: the two faces of health and disease Frontiers in Bioscience. ,vol. 12, pp. 5030- 5038 ,(2007) , 10.2741/2445
Ezio Giacobini, Patrizia DeSarno, Brent Clark, Michael McIlhany, Chapter 33 The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer Progress in Brain Research. ,vol. 79, pp. 335- 343 ,(1989) , 10.1016/S0079-6123(08)62493-0
Waldo Cerpa, Margarita Dinamarca, Nibaldo Inestrosa, Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses. Current Alzheimer Research. ,vol. 5, pp. 233- 243 ,(2008) , 10.2174/156720508784533321
Kenneth M. Lanzetta, Noriaki Yahata, Sebastian Pascarelle, Hsiao-Wen Chen, Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68 Nature. ,vol. 408, pp. 562- 564 ,(2000) , 10.1038/35046031
Takeshi Kihara, Shun Shimohama, Hideyuki Sawada, Kazuhiro Honda, Tomoki Nakamizo, Hiroshi Shibasaki, Toshiaki Kume, Akinori Akaike, α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity Journal of Biological Chemistry. ,vol. 276, pp. 13541- 13546 ,(2001) , 10.1074/JBC.M008035200
J.M. Candy, E.K. Perry, R.H. Perry, J.A. Court, A.E. Oakley, J.A. Edwardson, Chapter 7 The current status of the cortical cholinergic system in Alzheimer's disease and Parkinson's disease Progress in Brain Research. ,vol. 70, pp. 105- 132 ,(1986) , 10.1016/S0079-6123(08)64300-9
Azlina Ahmad-Annuar, Lorenza Ciani, Iordanis Simeonidis, Judit Herreros, Naila Ben Fredj, Silvana B. Rosso, Anita Hall, Stephen Brickley, Patricia C. Salinas, Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release Journal of Cell Biology. ,vol. 174, pp. 127- 139 ,(2006) , 10.1083/JCB.200511054
E. Masliah, L. Hansen, T. Albright, M. Mallory, R. D. Terry, Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease. Acta Neuropathologica. ,vol. 81, pp. 428- 433 ,(1991) , 10.1007/BF00293464
Dominic M. Walsh, Dennis J. Selkoe, A beta oligomers - a decade of discovery. Journal of Neurochemistry. ,vol. 101, pp. 1172- 1184 ,(2007) , 10.1111/J.1471-4159.2006.04426.X