Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells.

摘要: We have analyzed cells of the B lineage for expression Tp44 antigen, a 44,000 homodimer detected by monoclonal antibody 9.3 on approximately 80% mature human T lymphocytes. Previous evidence has suggested that may function as receptor accessory signals in cell activation. High level was observed plasmacytomas grown culture and plasma from bone marrow biopsies multiple myeloma patients. This antigen is not present resting either peripheral blood or lymphoid organs, any other tumor. The growth kinetics Ig production are affected binding 9.3. Moreover, molecule co-expressed with PCA-1, an characteristic cells, stimulated vitro to differentiate toward cells. represent later stage differentiation than PCA-1 because unlike this could be EBV-transformed line Burkitt's lymphoma lines. m.w. expressed identical, determined immunoprecipitation radioiodinated surface proteins might useful studying mechanism heterogeneity within populations, interactions components immune system.