Genes, pathways and checkpoints in lymphocyte development and homeostasis

摘要: A plethora of genes involved in murine B and T cell development have been identified, developmental pathways within the primary lymphoid tissues well delineated. The generation a functional, but non-self reacting lymphocyte repertoire results from completion several checkpoints during competition for survival factors periphery. Improved knowledge these homeostatic mechanisms is critical understanding human immunodeficiency, leukaemia/lymphoma autoimmunity, which are conditions where homeostasis likely to be deregulated.