Effects on the Immune System

摘要: Marijuana and other exogenous cannabinoids alter immune function decrease host resistance to microbial infections in experimental animal models vitro. Two modes of action by which Δ9-tetrahydrocannabinol (THC) affect responses have been proposed. First, may signal through the cannabinoid receptors CB1 CB2. Second, at sites direct exposure high concentrations cannabinoids, such as lung, membrane perturbation be involved. In addition, endogenous or endocannabinoids identified proposed native modulators functions receptors. Exogenously introduced disturb this homoeostatic balance. A mode perturbing balance T helper (Th)1 pro-inflammatory versus Th2 anti-inflammatory cytokines. While marijuana various documented vitro animals, no controlled longitudinal epidemiological studies yet definitively correlated immunosuppressive effects with increased incidence disorders humans. However, virtue their immunomodulatory properties potential serve therapeutic agents for ablation untoward responses.