The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities.
作者： Christopher D. Steele , Nischalan Pillay
DOI: 10.1016/J.SEMCANCER.2019.11.009
关键词:
摘要: Undifferentiated sarcoma of soft tissue (USTS) are aggressive sarcomas that remain a diagnosis exclusion and show extreme genomic complexity. Many advances in diagnostic criteria have resulted several revisions the definition this rare cancer type. Recent sequencing efforts illuminated nature genome complexity revealed extensive copy number heterogeneity multiple evolutionary patterns development. This review places these recent into their historical translational context covers changes nomenclature, molecular classification, promise personalised medicine.
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