International expert consensus on endpoints for full-thickness laparoendoscopic colonic excision.

摘要: Full-thickness laparoendoscopic excision has been reported for complex endoscopically unresectable colonic polyps. However, the endpoints used in these studies vary significantly and therefore making definitive conclusions regarding novel procedure would be improved if a common data set were adopted. This study sought to define most appropriate that should measured research on full-thickness of A Web-based Delphi Questionnaire was developed using systematic literature review endpoints. Outcomes grouped into general, complication, technical histopathology International specialists laparoscopic surgery, endoscopy transanal endoscopic microsurgery invited participate. The questionnaire required prioritization outcomes 5-point Likert scale. Respondents then sent second containing feedback scores from round 1 asked re-prioritize based received identify final core outcome set. total 33 (75 % response rate) participants 11 countries completed 28 proposed endpoints, all round. Eight rated important stakeholders within four domains—reoperation (general); anastomotic leak, mortality (complications); secure closure site, macroscopic completeness (technical); presence cancer, clearance resected margins en bloc specimen production (histopathology). provisional consensus minimum number feasible clinically meaningful measures use Widespread adoption will allow better reporting technique more efficient development clinical practice.