Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor.
作者： H. Herzog , M. Baumgartner , C. Vivero , L.A. Selbie , B. Auer
DOI: 10.1016/S0021-9258(18)53306-8
关键词:
摘要: A 14-kilobase pair (kb) region of genomic DNA encoding the human neuropeptide Y Y1-receptor gene including 3'- and 5'-flanking sequences has been cloned localized to chromosome 4q(31.3-32). In contrast contiguous structure most G protein-coupled receptor genes, NPY Y1 is divided into three exons. small 5'-exon mRNA untranslated separated by a 6-kb intron from second exon. The coding interrupted intron, containing an in-frame stop codon, shortly after proposed fifth transmembrane domain. potential cAMP-response element AP-2 site, in addition TATA-like sequence typical CAAT, box are present. single point mutation within generates PstI polymorphic site with highly informative allele frequency 54:46% population.
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