Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review.

摘要: Osteoarthritis (OA) refers to a chronic joint disease characterized by degenerative changes of articular cartilage and secondary bone hyperplasia. Since has special structure, namely the absence blood vessels as well low conversion rate chondrocytes in matrix, treatment faces numerous clinical challenges. Traditional OA (e.g., arthroscopic debridement, microfracture, autologous or allogeneic transplantation, chondrocyte transplantation) is primarily symptomatic pain management, which cannot contribute regenerating degenerated reducing inflammation. Also, generated mixed fibrous tissue not same natural hyaline cartilage. Mesenchymal stem cells (MSCs) have turned into most extensively explored new therapeutic drugs cell-based result their ability differentiate immunomodulatory properties. In this study, preliminary results preclinical (OA animal model)/clinical trials regarding effects MSCs on repair knee joints are briefly summarized, lay solid application basis for more deeper studies treatment.