A double-blind trial of long-term anticoagulant treatment after myocardial infarction.

摘要: A prospective double blind trial of long-term anticoagulant medication following myocardial infarction was carried out in Utrecht from May 1, 1964 to January 15, 1966. With the collaboration all cardiologists, their patients with acute were included this after a 4-month interval, be distributed strictly at random over phenprocoumon and placebo group. Supplemental therapy follow-up identical both groups. Of total 138 trial, 68 received 70 given placebo. One patient died group, eight This difference is significant (P < 0.01). The number reinfarctions not (5 cases 7 cases, respectively). After 1966, when between two groups had become significant, further treated phenprocoumon. Nevertheless, mortality continued through five deaths original group only one death group. The mean thrombotest level 10.7%; remained within therapeutic limits (5–15% thrombotest) during an average 91% entire period investigation. daily dose 3.21 mg. No serious haemorrhagic complications occurred. The results our study are consistent those several other recently published investigations. intensity hypocoagulability attained probably decisive importance respect. However, correct calculation difficult. The fact that less favourable even switch emphasizes necessity treatment adequate doses anticoagulants infarction.