Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases.
作者： Astrid J Schraa , Maaike Everts , Robbert J Kok , Dirk KF Meijer , Lou FMH de Leij
DOI: 10.1016/S1387-2656(02)08007-9
关键词:
摘要: Abstract Endothelial cells play a pathological role in cancer and chronic inflammation are therefore attractive targets for therapeutic intervention. This review focuses on endothelial cell specific drug targeting strategies the treatment of these diseases. The cellular molecular processes involved activation angiogenesis will be reviewed. Various target epitopes expressed by activated endothelium suitable purposes, design development drug-carrier complexes, drugs interest which might interfere with activation, as well vitro vivo experimental approaches to study (intra)cellular delivery discussed.
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