Perinatal Hypothyroidism Impairs the Normal Transition of GLUT4 and GLUT1 Glucose Transporters From Fetal to Neonatal Levels in Heart and Brown Adipose Tissue. Evidence for Tissue-Specific Regulation of GLUT4 Expression by Thyroid Hormone

摘要: GLUT1 and GLUT4 glucose transporter expression is highly regulated in muscle adipose tissue during perinatal life. Here we have investigated the role of thyroid hormones regulation induction repression associated to neonatal development. Perinatal hypothyroidism markedly impaired protein heart. This effect was heart specific, a greater detected brown from hypothyroid rats compared with controls. These changes were not or when induced adult rats. results indicate that life sensitive both tissue. characterized by decreased cardiac mRNA concentrations. T3 injection caused marked increase levels neonates. Thus, 13-day-old rats, increased 3-fold 1 h after injection. Under these conditions, retinoic acid also rapid In addition, fetuses neonates 24 findings suggest direct promotion gene expression. enhanced as well concomitant hearts Immunofluorescence analysis indicated cardiomyocytes pups contained an level protein. Furthermore, decrease hormone manipulation leads inverse We conclude play pivotal controlling transition carriers fetal