Effectiveness of a 16-Hour Transdermal Nicotine Patch in a Medical Practice Setting, Without Intensive Group Counseling

摘要: Background: To determine the effectiveness of a 16-hour transdermal nicotine patch in assisting smokers to stop smoking, when used primary medical practice model. Methods: A single-site, randomized, double-blind, outpatient, parallel-group, placebo-controlled trial consisting 220 regular, otherwise healthy cigarette smokers. Patients participated 12-week treatment phase plus 6-week tapering phase. standard office model physician intervention, such as could easily be employed by any care physician, without need for special psychological services, training, or skills, was behavioral intervention. Results: Sustained abstinence, determined at each visit absolutely no use, carbon monoxide level 9 ppm less, and serum cotinine 15 ng/mL less (after week 18), significantly greater those patients receiving active than placebo patch: percent not smoking 6,12,18,26, 52 weeks 61% vs 35%, 45% 26%, 41% 16%, 34% 12%, 25% 9%, respectively (P Conclusions: Nicotine replacement therapy via provided safe effective tobacco-dependent patients. One-year sustained nonsmoking rates were nearly three times higher condition, an applicable setting, interventions. This outcome good better results achieved patches using behavior modification group counseling. (Arch Intern Med. 1993;153:1881-1890)