Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion.

摘要: Abstract Paraplegia following complex aortic intervention relies on crude evaluation of lower extremity strength such as whether the patient can lift their legs or flex ankle. Little attention has been given to possible long-term neurologic sequelae these procedures in patients appearing functionally normal. We hypothesize that mice subjected minimal ischemic time will have functional and histological changes despite gross appearance normal function. Male underwent 3 min occlusion (n=14) sham surgery (n=4) via a median sternotomy. Neurologic function was graded by Basso Motor Score (BMS) preoperatively at 24 h intervals after reperfusion. Mice were placed walking beam recorded high-definition, for single-frame motion analysis. After 96hrs, spinal cords removed Following ischemia, outcomes split evenly with either displaying almost n=7 near complete paraplegia n=7. Additionally, analysis revealed significant gait. Histologically, there stepwise reduction neuronal viability, even group demonstrating loss neurons. Despite function, temporary ischemia induced marked cyto-architectural degeneration. Furthermore high-definition gait activity thoracic occlusion. These data suggest all undergoing procedures, short times, may cord injury is not evident clinically.