Inhibition of Ocular Angiogenesis by siRNA Targeting Vascular Endothelial Growth Factor Pathway Genes : Therapeutic Strategy for Herpetic Stromal Keratitis

摘要: Ocular neovascularization often results in vision impairment. Frequently vascular endothelial cell growth factors (VEGFs) are mainly responsible for the pathological as case induced by CpG oligodeoxynucleotides and herpes simplex virus infection this report. siRNAs targeting either VEGFA, VEGFR1, VEGFR2, or a mix of three were shown to significantly inhibit when given locally systemically. The efficacy systemic administration was facilitated use polymer delivery vehicle. Additional experiments showed significant inhibitory effect systemically vehicle against virus-induced angiogenesis well lesions stromal keratitis. These indicate that VEGF pathway-specific represents useful therapy neovascularization-related eye diseases.