CCAAT/Enhancer Binding Protein β Is a Neuronal Transcriptional Regulator Activated by Nerve Growth Factor Receptor Signaling

摘要: CCAAT/enhancer binding protein beta (C/EBPbeta) is a transcriptional regulator of the basic leucine zipper family. By in situ hybridization analysis, we found that C/EBPbeta widely expressed CNS adult mice, including cells hippocampus and dentate gyrus cerebellar Purkinje granule cells. Expression had also been reported PC12 cell line, which undergoes differentiation to neuron-like response nerve growth factor (NGF). We show mRNA expression increases while levels decrease during In transactivation assays, activity was stimulated by NGF receptor signaling. Mutations phosphorylation site for mitogen-activated kinase affected its capacity transactivate promoter-specific manner. Our data identify gene as direct downstream targets suggest role neurotrophin signaling brain.