miR-199a-5p inhibits proliferation and induces apoptosis in hemangioma cells through targeting HIF1A.
作者： Yang Wang , Yu-Xin Dai , Shu-Qing Wang , Ming-Ke Qiu , Zhi-Wei Quan
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摘要: MicroRNAs (miRNAs) exhibit a crucial role in the regulation of angiogenesis and tumor progression, which miR-199a-5p (miR-199a) has been reported to function as suppressor multiple malignancies. However, precise mechanisms underlying miR-199a hemangiomas (HAs) remain elusive. In this study, we found that had low expression level, while proliferating cell nuclear antigen (PCNA) high level proliferating-phase HAs compared with involuting-phase normal tissues. Spearman correlation analysis revealed negative PCNA HAs. vitro experiments showed restoration suppressed proliferation capability induced apoptosis HA-derived endothelial cells (HDEC) CRL-2586 EOMA cells, followed decreased increased cleaved caspase-3 expression, but inhibitor reversed these effects. Furthermore, HIF1A was identified target Overexpression attenuated anti-proliferation effect mimic cells. Taken together, our findings demonstrate may inhibit induce via targeting provide potential therapeutic for
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