Risk factors for human corneal graft failure within the Australian corneal graft registry.

摘要: Background. Our aims were to examine graft survival and visual outcome after full-thickness corneal transplantation. Methods. Records of 18,686 penetrating grafts, 14,622 with archival follow-up from 1 22 years, examined within a national database. Kaplan-Meier analysis indicated variables interest for Cox proportional hazards regression analysis. A model clustered by patient control intereye or intergraft dependence was constructed identify best predicting failure. Visual acuity in the grafted eye measured Snellen acuity. Results. Probability 0.87,0.73,0.60, 0.46 at 1,5, 10, 15 respectively. Reasons failure included irreversible rejection (34%), endothelial cell including cases glaucoma (24%), infection (14%). Variables multivariate transplant center, location volume surgeon's case-load, era, indication graft, number previous ipsilateral lens status, neovascularization transplantation, history ocular inflammation raised intraocular pressure, diameter, postoperative events rejection. Best-corrected 6/12 better achieved 45%, less than 6/60 26%, eyes last follow-up. Conclusions. The short-term transplants is excellent, but eventual attrition rate appears inexorable many factors that influence significantly are not amenable change. Most grafts performed improvement, excellent will be approximately half all grafts.