Emerging strategies and applications of pharmacogenomics.
作者： Patrice M Milos , Albert B Seymour
DOI: 10.1186/1479-7364-1-6-444
关键词:
摘要: The rapid pace of genomic science advancements, including the completion human genome sequence, extensive cataloguing genetic variation and acceleration technologies to assess such variation, combined with clinical programmes rich phenotypic data, serve as foundation for design execution pharmacogenomic studies which have an impact on pharmaceutical pipeline from early discovery through marketplace. authors discuss required infrastructure support provide insight into strategies practical application influence decision making in setting. Further, pharmacogenomics is currently affecting patient care oncology area highlighted evident
biomedcentral.com
springer.com
paperity.org参考文章(80)
Corinne Charlier, Franck Broly, Michel Lhermitte, Emmanuel Pinto, Marc Ansseau, Guy Plomteux, Polymorphisms in the CYP 2D6 gene: association with plasma concentrations of fluoxetine and paroxetine. Therapeutic Drug Monitoring. ,vol. 25, pp. 738- 742 ,(2003) , 10.1097/00007691-200312000-00014
M. Ingelman-Sundberg, Pharmacogenetics: an opportunity for a safer and more efficient pharmacotherapy. Journal of Internal Medicine. ,vol. 250, pp. 186- 200 ,(2001) , 10.1046/J.1365-2796.2001.00879.X
JANET D. ROWLEY, Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. ,vol. 243, pp. 290- 293 ,(1973) , 10.1038/243290A0
Mercedes E Gorre, Mansoor Mohammed, Katharine Ellwood, Nicholas Hsu, Ron Paquette, P Nagesh Rao, Charles L Sawyers, Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification Science. ,vol. 293, pp. 876- 880 ,(2001) , 10.1126/SCIENCE.1062538
M. Dean, M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study, S. J. O'Brien, , Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene Science. ,vol. 273, pp. 1856- 1862 ,(1996) , 10.1126/SCIENCE.273.5283.1856
Hagop Kantarjian, Charles Sawyers, Andreas Hochhaus, Francois Guilhot, Charles Schiffer, Carlo Gambacorti-Passerini, Dietger Niederwieser, Debra Resta, Renaud Capdeville, Ulrike Zoellner, Moshe Talpaz, Brian Druker, None, Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia The New England Journal of Medicine. ,vol. 346, pp. 645- 652 ,(2002) , 10.1056/NEJMOA011573
Christopher S. Carlson, Michael A. Eberle, Mark J. Rieder, Qian Yi, Leonid Kruglyak, Deborah A. Nickerson, Selecting a Maximally Informative Set of Single-Nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium American Journal of Human Genetics. ,vol. 74, pp. 106- 120 ,(2004) , 10.1086/381000
Alexander J. MacGregor, Leto Antoniades, Matthew Matson, Toby Andrew, Tim D. Spector, The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis & Rheumatism. ,vol. 43, pp. 2410- 2416 ,(2000) , 10.1002/1529-0131(200011)43:11<2410::AID-ANR6>3.0.CO;2-E
Hreinn Stefansson, Hannes Petursson, Engilbert Sigurdsson, Valgerdur Steinthorsdottir, Soley Bjornsdottir, Thordur Sigmundsson, Shyamali Ghosh, Jon Brynjolfsson, Steinunn Gunnarsdottir, Omar Ivarsson, Thomas T. Chou, Omar Hjaltason, Birgitta Birgisdottir, Helgi Jonsson, Vala G. Gudnadottir, Elsa Gudmundsdottir, Asgeir Bjornsson, Brynjolfur Ingvarsson, Andres Ingason, Sigmundur Sigfusson, Hronn Hardardottir, Richard P. Harvey, Donna Lai, Mingdong Zhou, Daniela Brunner, Vincent Mutel, Acuna Gonzalo, Greg Lemke, Jesus Sainz, Gardar Johannesson, Thorkell Andresson, Daniel Gudbjartsson, Andrei Manolescu, Michael L. Frigge, Mark E. Gurney, Augustine Kong, Jeffrey R. Gulcher, Kari Stefansson, Neuregulin 1 and Susceptibility to Schizophrenia American Journal of Human Genetics. ,vol. 71, pp. 877- 892 ,(2002) , 10.1086/342734
Magnus Ingelman-Sundberg, Mikael Oscarson, Roman A McLellan, Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment Trends in Pharmacological Sciences. ,vol. 20, pp. 342- 349 ,(1999) , 10.1016/S0165-6147(99)01363-2