Management of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).

摘要: Monoclonal gammopathy of undetermined significance (MGUS) is defined as a serum M protein level less than 3 g/dL, 10% clonal plasma cells in the bone marrow, and absence end-organ damage. The prevalence MGUS 3.2% white population but approximately twice that high black population. may progress to multiple myeloma, AL amyloidosis, Waldenstrom macroglobulinemia, or lymphoma. risk progression 1% per year, continues even after more 25 years observation. Risk factors for include size protein, type number free light chain ratio. Smoldering (asymptomatic) myeloma (SMM) characterized by presence an g/dL higher and/or monoclonal marrow no evidence overall malignant condition year first 5 years, 3% next 2% following 10 years. Patients with both SMM must be followed up their lifetime.