A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

摘要: The intestinal epithelium is a regenera-tive tissue that constantly renewed by small population of stem cells located in the crypts. Because this tis-sue subject to microbial and mechanical assault, it requires significant regenerative capacity order maintain its struc-ture. Defects homeostasis can have serious consequences for human health, unrestricted growth result colorectal cancer. A number studies implicated Src FAK colorec-tal cancer, however most these analyses focused on processes invasion metastasis, little was known about importance elevated Src/FAK at earliest stages cancer development.