Thyrotoxicosis and heart failure that complicate pregnancy

摘要: Abstract Objective When untreated, Graves' thyrotoxicosis has profound cardiovascular effects, although it rarely causes heart failure in otherwise healthy patients. Preliminary observations suggest that pregnant women are the exception. To further elucidate this association, we studied both immediate and long-term outcomes who had during pregnancy. Study design We reviewed clinical of with disease at our institution from 1974 through 2001. Women other underlying were excluded. A standardized antithyroid regimen serial echocardiography and/or chest radiography performed. Results The 13 either noncompliant therapy or no medical care Six before fetal viability; decompensation was precipitated by hemorrhage, sepsis, both. 7 last trimester when developed; 4 women, severe preeclampsia-eclampsia 2 sepsis. Overall, 11 an obstetric event. In follow-up to 25 years, resolution cardiomyopathy confirmed after successful treatment thyrotoxicosis. Conclusion Normal pregnancy mimics amplifies some hyperdynamic changes caused they occur simultaneously, there is usually a compensated high-output state. however, common complications include hemorrhage associated anemia, will precipitate failure. correction precipitating factors results good outcome. Long-term thyrotoxic cardiac dysfunction reversible therapy.