Novel Biocatalytic Polymer-Based Antimicrobial Coatings as Potential Ureteral Biomaterial: Preparation and In Vitro Performance Evaluation

摘要: Catheters and other indwelling devices placed inside human body are prone to bacterial infection, causing serious risk patients. Infections associated with implants difficult resolve, hence the prevention of colonization such surfaces is quite appropriate. In this context, development novel antimicrobial biomaterials currently gaining momentum. We describe here preparation antibacterial properties an enzyme-embedded polycaprolactone (PCL)-based coating, coimpregnated antibiotic gentamicin sulfate (GS). The enzyme uses PCL itself as substrate; a result, gets released at rate controlled by degradation base. vitro drug release studies demonstrated sustained GS from film throughout its lifetime. By modulating concentration in film, we were able vary lifetime coating 33 h 16 days. end, polymer completely degraded, delivering entire load antibiotic. exhibited against three test isolates: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus. Foley urinary catheters coated modified over 60-h period. results suggest that antibiotic-plus-enzyme-loaded can be used tunable self-degrading biomaterial on catheters.