作者: Richard C. Cabot , Robert E. Scully , Eugene J. Mark , Betty U. McNeely
DOI: 10.1056/NEJM198409063111008
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摘要: Presentation of Case A 15-year-old boy was admitted to the hospital because progressive neurologic deterioration. He well until 32 months earlier, when he began experience fatigue, pallor, and bruising. came this hospital, where physical examination showed anterior cervical lymphadenopalhy hepatosplenomegaly. Microscopical an aspirated specimen bone marrow revealed almost complete replacement by blasts, without evidence myeloid differentiation, diagnosis acute lymphocytic leukemia, null-cell type, made. Induction chemotherapy begun with vincristine, prednisone, levo-asparaginase. The patient responded promptly, spleen shrank rapidly. discharged home on . . .