Glioblastoma: Análisis molecular y sus implicancias clínicas

摘要: Glioblastoma (GB) is the most common and lethal primary brain tumor. Epidemiologic information indicate that its incidence lower in Hispanic race. Surgery only curative strategy has recently introduced new strategies increase resection rates. The use of concurrent chemotherapy with radiotherapy improves survival patients but associated toxicity. Improved understanding molecular biology GB allows identification predictive biomarkers response prognosis as well therapeutic targets for development strategies. Among are currently available 1p /19q codeletion, IDH mutation O6-methylguanine DNAmethyltransferase promoter methylation. enables drugs their evaluation clinical trials, none been prospectively validated phase III trials.