Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis

摘要: American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works investigated the effects on human-derived peripheral blood mononuclear cells (PBMC) leishmaniasis models. Thus, we investigate immunomodulatory treatment PBMC from ATL patients and healthy donors infected braziliensis. Our data demonstrate that pretreatment shows both adherent cells, increasing IL-4 IL-17 decreasing IL-10, either presence or absence L. braziliensis infection, demonstrating contributes decrease inflammation could also contribute parasite control.