Antidepressant-Like Effect of Chronic Taurine Administration and Its Hippocampal Signal Transduction in Rats

摘要: Taurine is one of the most abundant amino acids in central nervous system, and it has various important functions as a neuromodulator antioxidant. expected to be involved mental disorders such depression; however, knowledge its function relation depression limited. In this research, we tried elucidate effects taurine supplementation on antidepressant-like behaviors rats depression-related signal transduction hippocampus. behavioral tests, fed high (HT: 45 mmol/kg taurine) diet for 4 weeks (HT4w) showed decreased immobility forced swim test (FS) compared controls. On other hand, low (LT: 22.5 or an HT 2 (HT2w) did not show significant difference FS western blot analyses, expression glutamic acid decarboxylase (GAD) 65 GAD67 hippocampus was affected by supplementation. However, phosphorylation levels extracellular signal-regulated kinase1/2 (ERK1/2), protein kinase B (Akt), glycogen synthase kinase3 beta (GSK3β), cAMP response element-binding (CREB) were increased HT4w HT2w rats. Phosphorylated calcium/calmodulin-dependent II (CaMKII) only. Moreover, no changes these molecules observed 1 day. conclusion, our discoveries suggest that effect ability change signaling cascades