Determination and validation of principal gene products
作者： Michael L. Tress , Jan-Jaap Wesselink , Adam Frankish , Gonzalo López , Nick Goldman
DOI: 10.1093/BIOINFORMATICS/BTM547
关键词:
摘要: Motivation: Alternative splicing has the potential to generate a wide range of protein isoforms. For many computational applications and for experimental research, it is important be able concentrate on isoform that retains core biological function. genes this far from clear. Results: We have combined five methods into pipeline allows us detect principal variant gene. Most were based conservation between species, at level both gene protein. The used exonic structure, detection non-neutral evolution, functional residues, existence known structure abundance vertebrate orthologues. was determine 83% set well-annotated with multiple variants. Contact: [email protected] Supplementary information: Supplementary data are available Bioinformatics online.
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