S32 Childhood Wheeze Phenotypes Can Be Usefully Sub-Classified Using Longitudinal Lung Function and Atopic Sensitisation Data. Evidence from the Southampton Women’s Survey

摘要: Background Epidemiological phenotypes for childhood wheeze were first proposed by the Tucson Children’s Respiratory Study (TCRS), describing four distinct phenotypes. A new, six phenotype, characterisation has recently been Avon Longitudinal of Parents And Children (ALSPAC). No previous cohort included 1 year atopic sensitisation data with infant lung function in their analysis. Objectives To classify and 6 allergic at 1, 3 years from Southampton Women’s Survey (SWS) according to ALSPAC class pheno type model. contrast this TCRS assess clinical epidemiological utility. Methods At years, 926 children had assessment respiratory symptoms. Spirometry was measured 791 children, exhaled nitric oxide (n=589) methacholine challenge (n=234). 5–14 weeks age 95 these measured. Symptom on status obtained 6m, 12m, 2y, 3y 6y follow up classified into groups analyses (never, early, transient, intermediate-onset, late-onset persistent wheeze). Results Persistent intermediate-onset significantly associated atopy years. Late-onset not until wheezers lower infant(V’maxFRC p Conclusion The SWS maps well phenotype classification, demonstrating useful subdivision Lung successfully differentiate persistent, wheeze, whilst classical ‘transient early’ can be sub-classified that reflect early function. This potential significance research long term morbidity