Influenza virus resistance to neuraminidase inhibitors
作者： Dirk B. Mendel , Robert W. Sidwell
DOI: 10.1016/S1368-7646(98)80038-1
关键词:
摘要: The recent reports from Hong Kong of an avian influenza virus which caused the death six people has served to remind us constant threat pandemics posed by influenza. Recently, structure-based drug design resulted in discovery a new class antiviral agents specifically target neuraminidase. Two neuraminidase inhibitors are currently undergoing clinical evaluation for prevention and treatment infection man. Here we review results vitro vivo studies relating potential development resistance this compounds.
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