The Relationship Between N -acetylcysteine, Hyperbaric Oxygen, and Inflammation in a Rat Model of Acetaminophen-induced Nephrotoxicity
作者： Hakan Cermik , Mine Yavuz Taslipinar , Ibrahim Aydin , Mehmet Agilli , Fevzi Nuri Aydin
DOI: 10.1007/S10753-013-9649-4
关键词:
摘要: An overdose of acetaminophen (APAP) produces acute tubular necrosis. The aim this study was to observe the effects hyperbaric oxygen (HBO) only and combined with N-acetylcysteine (NAC) on inflammatory cytokines in kidney. Thirty-two male Sprague-Dawley rats were divided into four groups: sham, control (APAP), NAC, NAC + HBO. In APAP, NAC + HBO groups, renal injury induced by oral administration 1 g/kg APAP. NAC group received (100 mg/kg/day). mg/kg/day) intraperitoneally HBO underwent at 2.8 ATA pressure 100 % inhalation for 90 min every 12 h 5 days. Rats sham distilled water gastric tube. All animals killed 6 days after APAP or administration. Creatinine, urea, neopterin, tumor necrosis factor-α (TNF-α), interleukin (IL)-6 levels measured sera. There a significant increase serum creatinine urea compared (in both, p = 0.001). significantly decreased TNF-α, IL-6 group. caused renal. treatments reduced APAP-induced damage. results showed that dysfunction toxicity attenuated use treatments. combination might be recommended as an effective treatment modality nephrotoxicity.
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