Overexpression of GSE1 Related to Trastuzumab Resistance in Gastric Cancer Cells.
作者： Wenbin Wang , Shuanhu Wang , Xiao Yuan , Jun Li , A. man Xu
DOI: 10.1155/2021/8834923
关键词:
摘要: Gastric cancer is one of the most prevalent human cancers with poor prognosis. Trastuzumab a well-used targeted drug for gastric HER2 amplification. resistance restrains clinical use trastuzumab. In this study, we reported Gse1 coiled-coil protein (GSE1) promoted trastuzumab in HER2-positive cells. Acquired trastuzumab-resistant cells overexpressed GSE1, and depletion GSE1 decreased BCL-2 was downstream gene positively regulated by also performed promoting role A high level associated risk tumor lymph node metastasis higher stage patients. potential target that could be used therapy.
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