Interactions between Gut Microbiota and Immunomodulatory Cells in Rheumatoid Arthritis

摘要: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases caused by abnormal immune activation and tolerance. Immunomodulatory cells (ICs) play a critical role in maintenance homeostasis normal function pathogenesis RA. The human gastrointestinal tract inhabited trillions commensal microbiota on mucosal surface that fundamental induction, maintenance, host system. Gut dysbiosis can impact both local systemic systems further contribute to various diseases, such as neighbouring intestinal ICs located distinct mucosa may be likely intermediary which gut affect occurrence development However, reciprocal interaction between components their microbial metabolites with how this RA are not well studied. Therefore, better understanding microbiota, ICs, interactions might improve our knowledge mechanisms facilitate novel therapeutic approaches. In review, we have summarized roles immunopathogenesis RA, especially discussed strategies for treating targeting/regulating microbiota.