Antiviral properties of cobalt(III)-complexes.

摘要: We have investigated the potential antiviral activity of three cobalt(III) compounds. Two compounds, Co(III)-cyclen-methylbenzoic acid and its methyl ester derivative, are based on macrocyclic chelator, cyclen, were synthesized in our laboratory. Both compounds been shown to bind tightly nucleic acids hydrolyze phosphodiester bonds. However, neither compound exhibited any significant an vitro model Sindbis virus replication. In contrast, a third compound, Co(III)hexammine, significantly inhibited replication baby hamster kidney (BHK) cells dose- time-dependent manner. plaque assays, incubation Co(III)hexammine with resulted dose-dependent decrease when measured at both 24 48-h post-infection. Over concentration range 0-5mM IC(50) for inhibition viral was determined be 0.10+/-0.04mM 48h. Additionally, BHK cell monolayers pretreated 6h prior infection, optimal cellular morphology plasma membrane integrity observed 0.6-1.2mM Co(III)hexammine. Analysis by flow cytometry confirmed that mediated concomitant increase viability percentage virus-infected (IC(50)=0.13+/-0.04mM). Our findings demonstrate first time possesses potent activity. discuss within context ability further functionalize render it highly specific therapeutic reagent.